The crash on highway 63 on Wednesday has turned fatal, according to Boyle RCMP.
It happened at kilometer marker 73, just north of Wandering River.
The highway was shut down for almost the entire morning.
The incident involved a Ford Ranger and a Semi Trailer pulling two chemical trailers.
The investigation is ongoing, however Police say weather appears to have played a role.
The name of the deceased will not be released until next of kin is notified.
Police are now looking for anyone who might have witnessed the crash to call Boyle RCMP or Crimestoppers at 1-800-222-TIPS.